Anti-Human CDK9 Polyclonal Antibody (HW357024)

Name: Anti-Human CDK9 Polyclonal Antibody
Brand: abinScience
SKU: HW357024
Price: 96 USD
Availability: InStock

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Vista general

Número de catálogo

HW357024

Descripción

Anti-Human CDK9 Polyclonal Antibody (HW357024) is a rabbit polyclonal antibody detecting CDK9 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Danio rerio, Human, Xenopus laevis, and Gallus gallus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CDK9 (Asp104-Phe315).

Objetivo

CDK9

Purificación

Purified by antigen affinity column.

Número de acceso

P50750

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

Cyclin-dependent kinase 9, 2.7.11.22, 2.7.11.23, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9, CDC2L4, TAK

Fondo

Cyclin-dependent kinase 9 (CDK9) is a ~42 kDa protein. Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g.

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2. Ivanov, D. et al. (2000) Molecular and cellular biology 20, 2970-83. PMID: 10757782

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4. Lavoie, SB. et al. (2001) Journal of molecular biology 312, 675-85. PMID: 11575923

5. Bourgeois, CF. et al. (2002) Molecular and cellular biology 22, 1079-93. PMID: 11809800

6. Lin, X. et al. (2002) The Journal of biological chemistry 277, 16873-8. PMID: 11884399

7. Fujinaga, K. et al. (2004) Molecular and cellular biology 24, 787-95. PMID: 14701750

8. Jang, MK. et al. (2005) Molecular cell 19, 523-34. PMID: 16109376

9. Yang, Z. et al. (2005) Molecular cell 19, 535-45. PMID: 16109377

10. Yu, DS. et al. (2010) EMBO reports 11, 876-82. PMID: 20930849

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-CDK9 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse lung lysate
Lane 2: Rat brain lysate
Lane 3: Rat lung lysate