Anti-Human CDK9 Polyclonal Antibody (HW357024)

Name: Anti-Human CDK9 Polyclonal Antibody
Brand: abinScience
SKU: HW357024
Price: 96 USD
Availability: InStock

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Каталожный номер

HW357024

Описание

Anti-Human CDK9 Polyclonal Antibody (HW357024) is a rabbit polyclonal antibody detecting CDK9 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Danio rerio, Human, Xenopus laevis, and Gallus gallus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CDK9 (Asp104-Phe315).

Цель

CDK9

Очистка

Purified by antigen affinity column.

Номер доступа

P50750

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Альтернативные названия

Cyclin-dependent kinase 9, 2.7.11.22, 2.7.11.23, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9, CDC2L4, TAK

Фон

Cyclin-dependent kinase 9 (CDK9) is a ~42 kDa protein. Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g.

1. Fu, TJ. et al. (1999) The Journal of biological chemistry 274, 34527-30. PMID: 10574912

2. Ivanov, D. et al. (2000) Molecular and cellular biology 20, 2970-83. PMID: 10757782

3. Kim, JB. et al. (2001) The Journal of biological chemistry 276, 12317-23. PMID: 11145967

4. Lavoie, SB. et al. (2001) Journal of molecular biology 312, 675-85. PMID: 11575923

5. Bourgeois, CF. et al. (2002) Molecular and cellular biology 22, 1079-93. PMID: 11809800

6. Lin, X. et al. (2002) The Journal of biological chemistry 277, 16873-8. PMID: 11884399

7. Fujinaga, K. et al. (2004) Molecular and cellular biology 24, 787-95. PMID: 14701750

8. Jang, MK. et al. (2005) Molecular cell 19, 523-34. PMID: 16109376

9. Yang, Z. et al. (2005) Molecular cell 19, 535-45. PMID: 16109377

10. Yu, DS. et al. (2010) EMBO reports 11, 876-82. PMID: 20930849

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-CDK9 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse lung lysate
Lane 2: Rat brain lysate
Lane 3: Rat lung lysate