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| カタログ番号 | HW820013 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human CDKN2A/p16INK4a Nanobody (SAA2259) [SAA2259] (HW820013) is a alpaca monoclonal antibody detecting CDKN2A/p16INK4a in ELISA. Suitable for Human.
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| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-His | ||||
| クローンID | SAA2259 | ||||
| ターゲット | CDKN2A/p16INK4a | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >90% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q8N726 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | Tumor suppressor ARF, Alternative reading frame, ARF, Cyclin-dependent kinase inhibitor 2A, p14ARF, CDKN2A | ||||
| 背景 | Tumor suppressor ARF (CDKN2A/p16INK4a) is a ~13 kDa protein. Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CDKN2A/p16INK4a Nanobody (SAA2259)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
