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| カタログ番号 | HX024014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CENPE Polyclonal Antibody (HX024014) is a rabbit polyclonal antibody detecting CENPE in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CENPE (Ala2450-Arg2590). | ||||||||
| ターゲット | CENP-E, CENPE, Kinesin-related protein CENPE, Centromere-associated protein E, Centromere protein E, Kinesin-7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q02224 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Centromere-associated protein E (CENPE) is a ~316 kDa protein. Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends. Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized. 1. Shrestha, RL. et al. (2013) Current biology : CB 23, 1514-26. PMID: 23891108 2. Bancroft, J. et al. (2015) Journal of cell science 128, 171-84. PMID: 25395579 3. Thrower, DA. et al. (1995) The EMBO journal 14, 918-26. PMID: 7889940 4. Barisic, M. et al. (2015) Science (New York, N.Y.) 348, 799-803. PMID: 25908662 5. Gudimchuk, N. et al. (2013) Nature cell biology 15, 1079-1088. PMID: 23955301 6. Iemura, K. et al. (2015) Nature communications 6, 6447. PMID: 25743205 7. Liu, D. et al. (2007) The Journal of biological chemistry 282, 21415-24. PMID: 17535814 | ||||||||
| 注意事項 | For research use only. |
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