

| Número de catálogo | HP542014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human CEP19 (Met1-Asp133). | ||||||||
| Objetivo | Centrosomal protein of 19 kDa, C3orf34, Cep19, CEP19 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q96LK0 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Centrosomal protein of 19 kDa (CEP19) is a ~19 kDa protein. Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes. 1. Nishijima, Y. et al. (2017) Molecular biology of the cell 28, 1652-1666. PMID: 28428259 2. Kanie, T. et al. (2017) Developmental cell 42, 22-36.e12. PMID: 28625565 3. Mojarad, BA. et al. (2017) Open biology 7. PMID: 28659385 | ||||||||
| Nota | For research use only. |
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