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| カタログ番号 | HP591014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CERS2 (Asn81-Ser128). | ||||||||
| ターゲット | SP260, CERS2, LASS2, CerS2, TMSG1, Ceramide synthase 2, LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, Sphingosine N-acyltransferase CERS2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96G23 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ceramide synthase 2 (CERS2) is a ~44 kDa protein. Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. 1. Lahiri, S. et al. (2007) FEBS letters 581, 5289-94. PMID: 17977534 2. Laviad, EL. et al. (2008) The Journal of biological chemistry 283, 5677-84. PMID: 18165233 3. Mizutani, Y. et al. (2008) Journal of lipid research 49, 2356-64. PMID: 18541923 4. Spassieva, SD. et al. (2009) The Biochemical journal 424, 273-83. PMID: 19728861 5. Ohno, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18439-44. PMID: 20937905 6. Tidhar, R. et al. (2012) The Journal of biological chemistry 287, 3197-206. PMID: 22144673 7. Kim, HJ. et al. (2012) Journal of lipid research 53, 1701-7. PMID: 22661289 8. Sassa, T. et al. (2016) The Journal of biological chemistry 291, 7477-87. PMID: 26887952 9. Tidhar, R. et al. (2018) The Journal of biological chemistry 293, 9912-9921. PMID: 29632068 | ||||||||
| 注意事項 | For research use only. |
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