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| カタログ番号 | HP686014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CHCHD3 Polyclonal Antibody (HP686014) is a rabbit polyclonal antibody detecting CHCHD3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHCHD3 (Ser58-Gly227). | ||||||||
| ターゲット | MICOS complex subunit MIC19, Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, MINOS3, MIC19, CHCHD3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NX63 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | MICOS complex subunit MIC19 (CHCHD3) is a ~26 kDa protein. Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. 1. Ott, C. et al. (2015) PloS one 10, e0120213. PMID: 25781180 2. Stephan, T. et al. (2020) The EMBO journal 39, e104105. PMID: 32567732 3. Hu, C. et al. (2020) Cell death & disease 11, 940. PMID: 33130824 4. Liu, H. et al. (2012) PloS one 7, e34832. PMID: 22567091 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CHCHD3 polyclonal antibody at 1μg/ml on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: Hela cell lysate
Lane 3: Jurkat cell lysate
Lane 4: Hepg2 cell lysate
Lane 5: A549 cell lysate
Lane 6: 293T cell lysate
Lane 7: Mouse kidney lysate
Lane 8: Mouse liver lysate
Lane 9: Mouse heart lysate
Lane 10: Rat kidney lysate
Lane11: Rat Liver lysate
Lane12: Rat heart lysate
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