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| カタログ番号 | HA503014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CHEK1 Polyclonal Antibody (HA503014) is a rabbit polyclonal antibody detecting CHEK1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Gallus gallus, Mus musculus, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHEK1 (Met1-Asn266). | ||||||||
| ターゲット | CHEK1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14757 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Serine/threonine-protein kinase Chk1, 2.7.11.1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHEK1, CHK1 | ||||||||
| 背景 | Serine/threonine-protein kinase Chk1 (CHEK1) is a ~54 kDa protein. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. 1. Feijoo, C. et al. (2001) The Journal of cell biology 154, 913-23. PMID: 11535615 2. Zhao, H. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 14795-800. PMID: 12399544 3. Heffernan, TP. et al. (2002) Molecular and cellular biology 22, 8552-61. PMID: 12446774 4. Chen, MS. et al. (2003) Molecular and cellular biology 23, 7488-97. PMID: 14559997 5. Pichierri, P. et al. (2004) The EMBO journal 23, 1178-87. PMID: 14988723 6. Krämer, A. et al. (2004) Nature cell biology 6, 884-91. PMID: 15311285 7. Huang, X. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1065-70. PMID: 15650047 8. Sørensen, CS. et al. (2005) Nature cell biology 7, 195-201. PMID: 15665856 9. Yu, X. et al. (2020) Journal of hematology & oncology 13, 40. PMID: 32357935 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CHEK1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: PC-12 cell lysate
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