Anti-Human CHMP2A Polyclonal Antibody (HT433014)

Name: Anti-Human CHMP2A Polyclonal Antibody
Brand: abinScience
SKU: HT433014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HT433014

Description

Anti-Human CHMP2A Polyclonal Antibody (HT433014) is a rabbit polyclonal antibody detecting CHMP2A in ELISA, IHC, WB. Suitable for Human, Mouse, Danio rerio, Chicken, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CHMP2A (Pro11-Asn181).

Cible

Vps2-1, Putative breast adenocarcinoma marker BC-2, CHMP2A, hVps2-1, CHMP2a, Vacuolar protein sorting-associated protein 2-1, Charged multivesicular body protein 2a, CHMP2, BC2, Chromatin-modifying protein 2a

Purification

Purified by antigen affinity column.

Numéro d'accès

O43633

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Charged multivesicular body protein 2a (CHMP2A) is a ~25 kDa protein. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.

1. Guizetti, J. et al. (2011) Science (New York, N.Y.) 331, 1616-20. PMID: 21310966

2. Vietri, M. et al. (2015) Nature 522, 231-5. PMID: 26040712

3. Gu, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2166-E2175. PMID: 28242692

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human CHMP2A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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