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| カタログ番号 | HT433014 | ||||||||
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| 説明 |
Anti-Human CHMP2A Polyclonal Antibody (HT433014) is a rabbit polyclonal antibody detecting CHMP2A in ELISA, IHC, WB. Suitable for Human, Mouse, Danio rerio, Chicken, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHMP2A (Pro11-Asn181). | ||||||||
| ターゲット | Vps2-1, Putative breast adenocarcinoma marker BC-2, CHMP2A, hVps2-1, CHMP2a, Vacuolar protein sorting-associated protein 2-1, Charged multivesicular body protein 2a, CHMP2, BC2, Chromatin-modifying protein 2a | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43633 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Charged multivesicular body protein 2a (CHMP2A) is a ~25 kDa protein. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. 1. Guizetti, J. et al. (2011) Science (New York, N.Y.) 331, 1616-20. PMID: 21310966 2. Vietri, M. et al. (2015) Nature 522, 231-5. PMID: 26040712 3. Gu, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2166-E2175. PMID: 28242692 | ||||||||
| 注意事項 | For research use only. |
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