Anti-Human CHRNB4 Polyclonal Antibody (HB165014)

Name: Anti-Human CHRNB4 Polyclonal Antibody
Brand: abinScience
SKU: HB165014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HB165014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CHRNB4 (Arg22-Lys231).

Cible

CHRNB4, Neuronal acetylcholine receptor subunit beta-4

Purification

Purified by antigen affinity column.

Numéro d'accès

P30926

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor.

1. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005

2. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329

3. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494

4. Elliott, KJ. et al. (1996) Journal of molecular neuroscience : MN 7, 217-28. PMID: 8906617

5. Gerzanich, V. et al. (1997) Molecular pharmacology 51, 320-7. PMID: 9203638

6. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human CHRNB4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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