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| カタログ番号 | HB165014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHRNB4 (Arg22-Lys231). | ||||||||
| ターゲット | CHRNB4, Neuronal acetylcholine receptor subunit beta-4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30926 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor. 1. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005 2. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329 3. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494 4. Elliott, KJ. et al. (1996) Journal of molecular neuroscience : MN 7, 217-28. PMID: 8906617 5. Gerzanich, V. et al. (1997) Molecular pharmacology 51, 320-7. PMID: 9203638 6. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490 | ||||||||
| 注意事項 | For research use only. |
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