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| カタログ番号 | HP061014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CIAO2B Polyclonal Antibody (HP061014) is a rabbit polyclonal antibody detecting CIAO2B in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CIAO2B (Thr29-Ser163). | ||||||||
| ターゲット | Mitotic spindle-associated MMXD complex subunit MIP18, FAM96B, Protein FAM96B, MSS19-interacting protein of 18 kDa, CIAB, CIAO2B, MIP18, Cytosolic iron-sulfur assembly component 2B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y3D0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytosolic iron-sulfur assembly component 2B (CIAO2B) is a ~17 kDa protein. Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. 1. Gari, K. et al. (2012) Science (New York, N.Y.) 337, 243-5. PMID: 22678361 2. Stehling, O. et al. (2012) Science (New York, N.Y.) 337, 195-9. PMID: 22678362 3. Stehling, O. et al. (2013) Cell metabolism 18, 187-98. PMID: 23891004 4. Ben-Shimon, L. et al. (2018) Journal of cell science 131. PMID: 29848660 5. Ito, S. et al. (2010) Molecular cell 39, 632-40. PMID: 20797633 | ||||||||
| 注意事項 | For research use only. |
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