

| Каталожный номер | HF922014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human CIB2 Polyclonal Antibody (HF922014) is a rabbit polyclonal antibody detecting CIB2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CIB2 (Met1-Ile187). | ||||||||
| Цель | Calcium and integrin-binding family member 2, Kinase-interacting protein 2, KIP 2, CIB2, KIP2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O75838 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Calcium and integrin-binding family member 2 (CIB2) is a ~21 kDa protein. Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. 1. Riazuddin, S. et al. (2012) Nature genetics 44, 1265-71. PMID: 23023331 2. Seco, CZ. et al. (2016) European journal of human genetics : EJHG 24, 542-9. PMID: 26173970 3. Patel, K. et al. (2015) PloS one 10, e0133082. PMID: 26426422 | ||||||||
| Примечание | For research use only. |
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