Anti-Human CIP2A Polyclonal Antibody (HV712014)

Name: Anti-Human CIP2A Polyclonal Antibody
Brand: abinScience
SKU: HV712014
Price: 168 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HV712014

Description

Anti-Human CIP2A Polyclonal Antibody (HV712014) is a rabbit polyclonal antibody detecting Protein CIP2A. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CIP2A (Asp2-Glu560).

Cible

CIP2A, Cancerous inhibitor of PP2A, KIAA1524, Protein CIP2A, p90 autoantigen

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q8TCG1

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Protein CIP2A is a ~102 kDa protein. Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss.

1. Junttila, MR. et al. (2007) Cell 130, 51-62. PMID: 17632056

2. Adam, S. et al. (2021) Nature cancer 2, 1357-1371. PMID: 35121901

3. De Marco Zompit, M. et al. (2022) Nature communications 13, 4143. PMID: 35842428

4. Lin, YF. et al. (2023) Nature 618, 1041-1048. PMID: 37165191

5. Trivedi, P. et al. (2023) Nature 618, 1049-1056. PMID: 37316668

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human CIP2A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai