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Anti-Human CLCNKA Polyclonal Antibody (HA681014)

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Vista general
Número de catálogoHA681014
Descripción
Anti-Human CLCNKA Polyclonal Antibody (HA681014) is a rabbit polyclonal antibody detecting Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human CLCNKA (Ala507-Lys687).
Objetivo Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P51800, P51801
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Chloride channel protein ClC-Ka (CLCNKA) is a ~75 kDa protein. Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide. Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials.

1. Estévez, R. et al. (2001) Nature 414, 558-61. PMID: 11734858
2. Waldegger, S. et al. (2002) Pflugers Archiv : European journal of physiology 444, 411-8. PMID: 12111250
3. Nozu, K. et al. (2008) Journal of medical genetics 45, 182-6. PMID: 18310267
4. Janssen, AG. et al. (2009) Journal of the American Society of Nephrology : JASN 20, 145-53. PMID: 18776122
5. Riazuddin, S. et al. (2009) American journal of human genetics 85, 273-80. PMID: 19646679
6. Fischer, M. et al. (2010) Journal of the American Society of Nephrology : JASN 21, 1281-9. PMID: 20538786
Nota For research use only
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human CLCNKA Polyclonal Antibody

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