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Anti-Human CLCNKA Polyclonal Antibody (HA681014)

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Aperçu
Numéro de catalogueHA681014
Description
Anti-Human CLCNKA Polyclonal Antibody (HA681014) is a rabbit polyclonal antibody detecting Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human CLCNKA (Ala507-Lys687).
Cible Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P51800, P51801
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Chloride channel protein ClC-Ka (CLCNKA) is a ~75 kDa protein. Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide. Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials.

1. Estévez, R. et al. (2001) Nature 414, 558-61. PMID: 11734858
2. Waldegger, S. et al. (2002) Pflugers Archiv : European journal of physiology 444, 411-8. PMID: 12111250
3. Nozu, K. et al. (2008) Journal of medical genetics 45, 182-6. PMID: 18310267
4. Janssen, AG. et al. (2009) Journal of the American Society of Nephrology : JASN 20, 145-53. PMID: 18776122
5. Riazuddin, S. et al. (2009) American journal of human genetics 85, 273-80. PMID: 19646679
6. Fischer, M. et al. (2010) Journal of the American Society of Nephrology : JASN 21, 1281-9. PMID: 20538786
Note For research use only
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Reférences
Fiche technique
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human CLCNKA Polyclonal Antibody

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