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| カタログ番号 | HA366023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, FACS, Functional assay | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | BDC-3042 | ||||
| ターゲット | C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLEC6A, CLECSF10, DC-associated C-type lectin 2, DECTIN2, Dectin-2, Dendritic cell-associated C-type lectin 2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q6EIG7 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | C-type lectin domain family 6 member A (CLEC6A/Dectin-2) is a ~23 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. 1. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656 2. Feinberg, H. et al. (2017) The Journal of biological chemistry 292, 13402-13414. PMID: 28652405 | ||||
| 注意事項 | For research use only |
SDS-PAGE for Anti-Human CLEC6A/Dectin-2 Antibody (BDC-3042)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
