Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042) (HA366023)

Name: Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042)
Brand: abinScience
SKU: HA366023
Price: 191 USD
Availability: InStock

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Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HA366023

Реактивность видов

Human

Применения

ELISA, FACS, Functional assay

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

BDC-3042

Цель

C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLEC6A, CLECSF10, DC-associated C-type lectin 2, DECTIN2, Dectin-2, Dendritic cell-associated C-type lectin 2

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

Q6EIG7

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

C-type lectin domain family 6 member A (CLEC6A/Dectin-2) is a ~23 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

1. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656

2. Feinberg, H. et al. (2017) The Journal of biological chemistry 292, 13402-13414. PMID: 28652405

Примечание

For research use only

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human CLEC6A/Dectin-2 Antibody (BDC-3042)

Ссылки

Даташит

Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа