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Anti-Human CLNS1A Polyclonal Antibody (HD609014)

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Anti-Human CLNS1A Polyclonal Antibody
Anti-Human CLNS1A Polyclonal Antibody
Precio(USD): --
Especificación:
  • 50ug
  • 100ug
Número:
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Vista general
Número de catálogoHD609014
Descripción
Anti-Human CLNS1A Polyclonal Antibody (HD609014) is a rabbit polyclonal antibody detecting CLNS1A. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CLNS1A (Met1-Leu135).
Objetivo CLCI, CLNS1A, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, ClCI, I(Cln), ICLN, Methylosome subunit pICln, Reticulocyte pICln
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P54105
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Methylosome subunit pICln (CLNS1A) is a ~26 kDa protein. Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

1. Pu, WT. et al. (1999) Molecular and cellular biology 19, 4113-20. PMID: 10330151
2. Friesen, WJ. et al. (2001) Molecular and cellular biology 21, 8289-300. PMID: 11713266
3. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161
4. Guderian, G. et al. (2011) The Journal of biological chemistry 286, 1976-86. PMID: 21081503
Nota For research use only
Imágenes
  • Anti-Human CLNS1A Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-CLNS1A polyclonal antibody at 1ug/mL on various samples.
    Lane 1: HT-29 cell lysate
    Lane 2: 293T cell lysate
    Lane 3: Hela cell lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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