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| カタログ番号 | HT219014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CLOCK (Ser106-Gly390). | ||||||||
| ターゲット | hCLOCK, bHLHe8, Class E basic helix-loop-helix protein 8, BHLHE8, Circadian locomoter output cycles protein kaput, CLOCK, KIAA0334 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15516 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Circadian locomoter output cycles protein kaput (CLOCK) is a ~95 kDa protein. Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). 1. Wang, Z. et al. (2013) Cell research 23, 213-24. PMID: 23229515 2. Charmandari, E. et al. (2011) PloS one 6, e25612. PMID: 21980503 3. Lin, R. et al. (2017) Molecular cell 68, 198-209.e6. PMID: 28985504 | ||||||||
| 注意事項 | For research use only. |
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