Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Name: Anti-Human CMPK2 Polyclonal Antibody
Brand: abinScience
SKU: HA833014
Price: 96 USD
Availability: InStock

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Spécification :

20ug
50ug
100ug

Nombre :

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HA833014

Description

Anti-Human CMPK2 Polyclonal Antibody (HA833014) is a rabbit polyclonal antibody detecting mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human CMPK2 (Leu99-Pro449).

Cible

UMP-CMP kinase 2, mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q5EBM0

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

UMP-CMP kinase 2, mitochondrial (CMPK2) is a ~49 kDa protein. Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor.

1. Xu, Y. et al. (2008) The Journal of biological chemistry 283, 1563-1571. PMID: 17999954

2. El-Diwany, R. et al. (2018) Science advances 4, eaat0843. PMID: 30083606

3. Zhu, M. et al. (2023) PLoS biology 21, e3002039. PMID: 36930652

4. Pawlak, JB. et al. (2023) PLoS pathogens 19, e1011286. PMID: 37075076

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-CMPK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate

Reférences

Fiche technique

Anti-Human CMPK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Aperçu

Images

Reférences

Fiche technique

SDS