Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Name: Anti-Human CMPK2 Polyclonal Antibody
Brand: abinScience
SKU: HA833014
Price: 96 USD
Availability: InStock

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SDS

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Каталожный номер

HA833014

Описание

Anti-Human CMPK2 Polyclonal Antibody (HA833014) is a rabbit polyclonal antibody detecting mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human CMPK2 (Leu99-Pro449).

Цель

UMP-CMP kinase 2, mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q5EBM0

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

UMP-CMP kinase 2, mitochondrial (CMPK2) is a ~49 kDa protein. Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor.

1. Xu, Y. et al. (2008) The Journal of biological chemistry 283, 1563-1571. PMID: 17999954

2. El-Diwany, R. et al. (2018) Science advances 4, eaat0843. PMID: 30083606

3. Zhu, M. et al. (2023) PLoS biology 21, e3002039. PMID: 36930652

4. Pawlak, JB. et al. (2023) PLoS pathogens 19, e1011286. PMID: 37075076

Примечание

For research use only

Изображения

Western blot

Western blot analysis was performed using anti-CMPK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate

Ссылки

Даташит

Anti-Human CMPK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Обзор

Изображения

Ссылки

Даташит

SDS