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| カタログ番号 | HD496013 |
|---|---|
| 説明 |
Anti-Human CMTM6 Nanobody (SAA2685) [SAA2685] (HD496013) is a alpaca monoclonal antibody detecting CMTM6 in ELISA. Suitable for Human.
|
| 種反応性 | Human |
| アプリケーション | ELISA |
| 宿主種 | Alpaca |
| クローン性 | Monoclonal |
| アイソタイプ | VHH-8His |
| クローンID | SAA2685 |
| ターゲット | CKLF-like MARVEL transmembrane domain-containing protein 6, CKLFSF6, CMTM6, Chemokine-like factor superfamily member 6 |
| エンドトキシンレベル | <10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9NX76 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a ~20 kDa protein. Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| 注意事項 | For research use only |
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