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| カタログ番号 | HA970014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CNOT7 Polyclonal Antibody (HA970014) is a rabbit polyclonal antibody detecting CNOT7 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CNOT7 (Arg11-Ser285). | ||||||||
| ターゲット | CNOT7, BTG1-binding factor 1, CAF-1, CAF1, Caf1a, CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UIV1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CCR4-NOT transcription complex subunit 7 (CNOT7) is a ~32 kDa protein. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. 1. Horiuchi, M. et al. (2009) The Journal of biological chemistry 284, 13244-55. PMID: 19276069 2. Cooke, A. et al. (2010) The Journal of biological chemistry 285, 28506-13. PMID: 20634287 3. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 31439799 4. Aslam, A. et al. (2009) Molecular biology of the cell 20, 3840-50. PMID: 19605561 5. Piao, X. et al. (2010) Molecular and cellular biology 30, 1486-94. PMID: 20065043 6. Doidge, R. et al. (2012) PloS one 7, e51331. PMID: 23236473 | ||||||||
| 注意事項 | For research use only. |
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