

| Numéro de catalogue | HY072014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human CNP Polyclonal Antibody (HY072014) is a rabbit polyclonal antibody detecting CNP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CNP (Glu40-Gly396). | ||||||||
| Cible | CNPase, 2', 3'-cyclic-nucleotide 3'-phosphodiesterase, CNP | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P09543 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) is a ~47 kDa protein. Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions. 1. Logue, J. et al. (2023) PLoS pathogens 19, e1011870. PMID: 38117830 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-CNP polyclonal antibody at 1μg/ml on various samples.
Lane 1: HepG2 cell lysate
Lane 2: U251 cell lysate
Lane 3: Hela cell lysate
Lane 4: Mouse brain lysate
Lane 5: Mouse cerebellum lysate
Lane 6: Rat brain lysate
Lane 7: Rat cerebellum lysate
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