Anti-Human Cannabinoid R1/CB1/CNR1 Recombinant Antibody (SAA0121), FITC (HB822117)

Name: Anti-Human Cannabinoid R1/CB1/CNR1 Recombinant Antibody (SAA0121), FITC
Brand: abinScience
SKU: HB822117
Price: 223 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HB822117
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG4, kappa
ID de clone	SAA0121
Conjugaison	FITC
Cible	CNR1, CB1, CANN6, CB-R, CNR, Cannabinoid receptor 1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), FITC
Numéro d'accès	P21554
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. 1. Ryberg, E. et al. (2005) FEBS letters 579, 259-64. PMID: 15620723 2. Hua, T. et al. (2016) Cell 167, 750-762.e14. PMID: 27768894 3. Shao, Z. et al. (2016) Nature 540, 602-606. PMID: 27851727 4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350 5. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 1718258 6. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 21895628 7. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 17895407 8. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human Cannabinoid R1/CB1/CNR1 Recombinant Antibody (SAA0121), FITC.pdf

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