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| カタログ番号 | HT436014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human COPE Polyclonal Antibody (HT436014) is a rabbit polyclonal antibody detecting COPE in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human COPE (Glu18-Ala308). | ||||||||
| ターゲット | Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14579 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Coatomer subunit epsilon (COPE) is a ~34 kDa protein. The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-COPE polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Hela cell lysate
Lane 3: Lncap cell lysate
Lane 4: A375 cell lsyate
Lane 5: 293T cell lysate
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