

| Каталожный номер | HP475014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human COPS8 Polyclonal Antibody (HP475014) is a rabbit polyclonal antibody detecting COPS8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human COPS8 (Met1-Lys166). | ||||||||
| Цель | hCOP9, COPS8, COP9 signalosome complex subunit 8, COP9 homolog, Signalosome subunit 8, JAB1-containing signalosome subunit 8, SGN8, CSN8 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q99627 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | COP9 signalosome complex subunit 8 (COPS8) is a ~23 kDa protein. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. | ||||||||
| Примечание | For research use only. |
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