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| カタログ番号 | HT054014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human COX7A2L Polyclonal Antibody (HT054014) is a rabbit polyclonal antibody detecting COX7A2L in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human COX7A2L (Met1-Lys114). | ||||||||
| ターゲット | EB1, COX7RP, Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7A2L, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, COX7AR | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14548 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytochrome c oxidase subunit 7A2-like, mitochondrial (COX7A2L) is a ~12 kDa protein. Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism. Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association. Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV. Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV. The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis. 1. Pérez-Pérez, R. et al. (2016) Cell reports 16, 2387-98. PMID: 27545886 2. Lobo-Jarne, T. et al. (2018) Cell reports 25, 1786-1799.e4. PMID: 30428348 3. Fernández-Vizarra, E. et al. (2021) Biochimica et biophysica acta. Bioenergetics 1862, 148414. PMID: 33727070 4. Fernández-Vizarra, E. et al. (2022) Cell metabolism 34, 1792-1808.e6. PMID: 36198313 | ||||||||
| 注意事項 | For research use only. |
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