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Anti-Human CPSF6 Polyclonal Antibody (HS787014)

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Vista general
Número de catálogoHS787014
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CPSF6 (Lys79-Ser181).
Objetivo Pre-mRNA cleavage factor Im 68 kDa subunit, CFIM68, Protein HPBRII-4/7, Cleavage and polyadenylation specificity factor subunit 6, CPSF6, CFIm68, CPSF 68 kDa subunit, Cleavage and polyadenylation specificity factor 68 kDa subunit, Cleavage factor Im complex 68 kDa subunit
Purificación Purified by antigen affinity column.
Número de acceso Q16630
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) is a ~59 kDa protein. Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery.

1. Brown, KM. et al. (2003) Molecular cell 12, 1467-76. PMID: 14690600
2. Zhu, Y. et al. (2018) Molecular cell 69, 62-74.e4. PMID: 29276085
3. Rüegsegger, U. et al. (1996) The Journal of biological chemistry 271, 6107-13. PMID: 8626397
4. Rüegsegger, U. et al. (1998) Molecular cell 1, 243-53. PMID: 9659921
5. Gruber, AR. et al. (2012) RNA biology 9, 1405-12. PMID: 23187700
6. Kim, S. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 1003-13. PMID: 20695905
Nota For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human CPSF6 Polyclonal Antibody

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