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Anti-Human CRCP Polyclonal Antibody (HF859014)

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Vista general
Número de catálogoHF859014
Descripción
Anti-Human CRCP Polyclonal Antibody (HF859014) is a rabbit polyclonal antibody detecting CRCP in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CRCP (Ser12-Ala148).
Objetivo CGRPRCP, HsC17, Calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CRCP, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, CGRP-receptor component protein
Purificación Purified by antigen affinity column.
Número de acceso O75575
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

DNA-directed RNA polymerase III subunit RPC9 (CRCP) is a ~16 kDa protein. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response.

1. Canella, D. et al. (2010) Genome research 20, 710-21. PMID: 20413673
2. Girbig, M. et al. (2021) Nature structural & molecular biology 28, 210-219. PMID: 33558764
3. Hou, H. et al. (2021) Nature communications 12, 6135. PMID: 34675218
4. Wang, Q. et al. (2021) Nature structural & molecular biology 28, 220-227. PMID: 33558766
5. Ablasser, A. et al. (2009) Nature immunology 10, 1065-72. PMID: 19609254
6. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human CRCP Polyclonal Antibody

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