

| Каталожный номер | HF859014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human CRCP Polyclonal Antibody (HF859014) is a rabbit polyclonal antibody detecting CRCP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CRCP (Ser12-Ala148). | ||||||||
| Цель | CGRPRCP, HsC17, Calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CRCP, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, CGRP-receptor component protein | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O75575 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | DNA-directed RNA polymerase III subunit RPC9 (CRCP) is a ~16 kDa protein. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. 1. Canella, D. et al. (2010) Genome research 20, 710-21. PMID: 20413673 2. Girbig, M. et al. (2021) Nature structural & molecular biology 28, 210-219. PMID: 33558764 3. Hou, H. et al. (2021) Nature communications 12, 6135. PMID: 34675218 4. Wang, Q. et al. (2021) Nature structural & molecular biology 28, 220-227. PMID: 33558766 5. Ablasser, A. et al. (2009) Nature immunology 10, 1065-72. PMID: 19609254 6. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370 | ||||||||
| Примечание | For research use only. |
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