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| カタログ番号 | HP069013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||
| アプリケーション | ELISA, IF, IHC, WB | ||||||
| 宿主種 | Mouse | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG2a | ||||||
| クローンID | 3E10# | ||||||
| ターゲット | RPRD1B, CREPT, Regulation of nuclear pre-mRNA domain-containing protein 1B, Cell cycle-related and expression-elevated protein in tumor | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | Q9NQG5 | ||||||
| RRID | Anti-Human CREPT Antibody (3E10#) (abinScience Cat# HP069013, RRID:AB_3726982) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Regulation of nuclear pre-mRNA domain-containing protein 1B (CREPT/RPRD1B) is a ~36 kDa protein. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. | ||||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CREPT Antibody (3E10#)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
