

| Каталожный номер | HP069013 | ||||||
|---|---|---|---|---|---|---|---|
| Реактивность видов | Human | ||||||
| Применения | ELISA, IF, IHC, WB | ||||||
| Хозяинский вид | Mouse | ||||||
| Клоональность | Monoclonal | ||||||
| Изотип | IgG2a | ||||||
| ID клона | 3E10# | ||||||
| Цель | RPRD1B, CREPT, Regulation of nuclear pre-mRNA domain-containing protein 1B, Cell cycle-related and expression-elevated protein in tumor | ||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||||
| Номер доступа | Q9NQG5 | ||||||
| RRID | Anti-Human CREPT Antibody (3E10#) (abinScience Cat# HP069013, RRID:AB_3726982) |
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| Форма | Liquid | ||||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| Фон | Regulation of nuclear pre-mRNA domain-containing protein 1B (CREPT/RPRD1B) is a ~36 kDa protein. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. | ||||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human CREPT Antibody (3E10#)
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