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| カタログ番号 | HX027014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014) is a rabbit polyclonal antibody detecting CSNK2A1 in ELISA, WB. Suitable for Mouse, Bovine, Chicken, Human, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CSNK2A1/CK2A1 (Asp14-Ser337). | ||||||||
| ターゲット | CSNK2A1, CK II alpha, CK2A1, Casein kinase II subunit alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P68400, Q60737, Q8NEV1, P19139, P19784, O54833 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Casein kinase II subunit alpha (CSNK2A1/CK2A1) is a ~45 kDa protein. Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. 1. Keller, DM. et al. (2001) Molecular cell 7, 283-92. PMID: 11239457 2. Sayed, M. et al. (2001) Oncogene 20, 6994-7005. PMID: 11704824 3. Shin, S. et al. (2005) The EMBO journal 24, 3532-42. PMID: 16193064 4. Melander, F. et al. (2008) The Journal of cell biology 181, 213-26. PMID: 18411307 5. Chapman, JR. et al. (2008) EMBO reports 9, 795-801. PMID: 18583988 6. Wu, L. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 11200-5. PMID: 18678890 7. St-Denis, NA. et al. (2009) Molecular and cellular biology 29, 2068-81. PMID: 19188443 8. Takeishi, Y. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 761-71. PMID: 20545769 9. Hung, MS. et al. (2010) PloS one 5, e11418. PMID: 20625391 10. Matsumoto, G. et al. (2011) Molecular cell 44, 279-89. PMID: 22017874 | ||||||||
| 注意事項 | For research use only. |
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