Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014)

Name: Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody
Brand: abinScience
SKU: HX027014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HX027014

Описание

Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014) is a rabbit polyclonal antibody detecting CSNK2A1 in ELISA, WB. Suitable for Mouse, Bovine, Chicken, Human, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CSNK2A1/CK2A1 (Asp14-Ser337).

Цель

CSNK2A1, CK II alpha, CK2A1, Casein kinase II subunit alpha

Очистка

Purified by antigen affinity column.

Номер доступа

P68400, Q60737, Q8NEV1, P19139, P19784, O54833

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Casein kinase II subunit alpha (CSNK2A1/CK2A1) is a ~45 kDa protein. Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.

1. Keller, DM. et al. (2001) Molecular cell 7, 283-92. PMID: 11239457

2. Sayed, M. et al. (2001) Oncogene 20, 6994-7005. PMID: 11704824

3. Shin, S. et al. (2005) The EMBO journal 24, 3532-42. PMID: 16193064

4. Melander, F. et al. (2008) The Journal of cell biology 181, 213-26. PMID: 18411307

5. Chapman, JR. et al. (2008) EMBO reports 9, 795-801. PMID: 18583988

6. Wu, L. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 11200-5. PMID: 18678890

7. St-Denis, NA. et al. (2009) Molecular and cellular biology 29, 2068-81. PMID: 19188443

8. Takeishi, Y. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 761-71. PMID: 20545769

9. Hung, MS. et al. (2010) PloS one 5, e11418. PMID: 20625391

10. Matsumoto, G. et al. (2011) Molecular cell 44, 279-89. PMID: 22017874

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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