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| カタログ番号 | HW518033 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human CTNNB1 Nanobody (SAA1410) [SAA1410] (HW518033) is a alpaca monoclonal antibody detecting Human CTNNB1 in ELISA. Suitable for Human.
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| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-His | ||||
| クローンID | SAA1410 | ||||
| ターゲット | BC2 peptide-tag, BC2e-tag, PDRKAAVSHWQQ | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by Nickel column. | ||||
| アクセッション番号 | P35222 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Catenin beta-1 (CTNNB1) is a ~85 kDa protein. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Also acts as a coactivator for other transcription factors, such as NR5A2. Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes. 1. Lillehoj, EP. et al. (2007) Biochimica et biophysica acta 1773, 1028-38. PMID: 17524503 2. Weiske, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 20344-9. PMID: 18077326 3. Bahmanyar, S. et al. (2008) Genes & development 22, 91-105. PMID: 18086858 4. Li, H. et al. (2009) The Journal of biological chemistry 284, 2012-22. PMID: 18957423 5. Fiset, A. et al. (2011) Cellular signalling 23, 911-9. PMID: 21262353 6. Satow, R. et al. (2012) Gastroenterology 142, 572-81. PMID: 22155184 7. Genovese, G. et al. (2012) Cell cycle (Georgetown, Tex.) 11, 2206-15. PMID: 22647378 8. Yu, Y. et al. (2012) EMBO reports 13, 750-8. PMID: 22699938 10. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CTNNB1 Nanobody (SAA1410)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
