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| カタログ番号 | HC301014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CUL2 Polyclonal Antibody (HC301014) is a rabbit polyclonal antibody detecting CUL2 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CUL2 (Thr526-Ala745). | ||||||||
| ターゲット | Cullin-2, CUL2, CUL-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13617 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cullin-2 (CUL2) is a ~86 kDa protein. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). 1. Kamura, T. et al. (2001) The Journal of biological chemistry 276, 29748-53. PMID: 11384984 2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980 3. Lin, HC. et al. (2018) Molecular cell 70, 602-613.e3. PMID: 29775578 4. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948 5. Zhao, S. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2308870120. PMID: 37844242 6. Liwocha, J. et al. (2024) Nature structural & molecular biology 31, 378-389. PMID: 38326650 7. Kamura, T. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 10430-5. PMID: 10973499 8. Min, KW. et al. (2003) The Journal of biological chemistry 278, 15905-10. PMID: 12609982 9. Kelsall, IR. et al. (2013) The EMBO journal 32, 2848-60. PMID: 24076655 | ||||||||
| 注意事項 | For research use only. |
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