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| カタログ番号 | HC617014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CUL4B Polyclonal Antibody (HC617014) is a rabbit polyclonal antibody detecting CUL4B in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CUL4B (Gly728-Ala913). | ||||||||
| ターゲット | Cullin-4B, CUL-4B, CUL4B, KIAA0695 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13620 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cullin-4B (CUL4B) is a ~103 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. 1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910 2. Higa, LA. et al. (2006) Cell cycle (Georgetown, Tex.) 5, 71-7. PMID: 16322693 3. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110 4. Guerrero-Santoro, J. et al. (2008) Cancer research 68, 5014-22. PMID: 18593899 5. Fischer, ES. et al. (2011) Cell 147, 1024-39. PMID: 22118460 6. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948 7. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453 8. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232 9. Chaikovsky, AC. et al. (2021) Nature 592, 794-798. PMID: 33854239 10. Sjögren, B. et al. (2015) PloS one 10, e0123581. PMID: 25970626 | ||||||||
| 注意事項 | For research use only. |
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