Anti-Human CXCL4/PF4 Recombinant Antibody (SAA0463) (HY443107)

Name: Anti-Human CXCL4/PF4 Recombinant Antibody (SAA0463)
Brand: abinScience
SKU: HY443107
Price: 196 USD
Availability: InStock

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概要
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参考文献
データシート
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概要

カタログ番号	HY443107
種反応性	Human
アプリケーション	ELISA, FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2a, kappa
クローンID	SAA0463
ターゲット	C-X-C motif chemokine 4, PF-4, Oncostatin-A, Endothelial cell growth inhibitor, CXCL4, Iroplact, Platelet factor 4, PF4, SCYB4
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P02776
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.09% Sodium azide. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Platelet factor 4 (CXCL4/PF4) is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. 1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254 2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587 3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362 4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069 5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499 6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347 7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524
注意事項	For research use only.

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Bioactivity

Detects Human CXCL4/ PF4 in indirect ELISAs.

参考文献

データシート

Anti-Human CXCL4/PF4 Recombinant Antibody (SAA0463).pdf

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Formula

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Anti-Human CXCL4/PF4 Recombinant Antibody (SAA0463) (HY443107)

概要

イメージ

参考文献

データシート

SDS

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お問い合わせ