Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

Name: Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4)
Brand: abinScience
SKU: HY443043
Price: 126 USD
Availability: InStock

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1mg

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概要
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概要

カタログ番号

HY443043

説明

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043) is a mouse monoclonal antibody detecting CXCL4/PF4 in ELISA, FCM, Functional. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human

アプリケーション

ELISA, FCM, Functional

宿主種

Mouse

クローン性

Monoclonal

アイソタイプ

IgG1, kappa

クローンID

U.Penn. patent anti-PF4

ターゲット

Platelet factor 4, PF-4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A, Platelet factor 4 short form, Endothelial cell growth inhibitor, PF4, CXCL4, SCYB4

エンドトキシンレベル

< 10 EU/mg as determined by LAL method.

純度

>95% as determined by SDS-PAGE.

精製

Protein A/G purified from cell culture supernatant.

アクセッション番号

P02776

形態

Liquid

保存バッファー

0.01M PBS pH 7.4

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:2000-1:20000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Platelet factor 4 (CXCL4/PF) is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence.

1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254

2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587

3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362

4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069

5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499

6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347

7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524

注意事項

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

イメージ

SDS-PAGE

SDS-PAGE for Anti-Human CXCL4/PF4 Antibody (U.Penn. patent anti-PF4)

参考文献

データシート

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

概要

イメージ

参考文献

データシート

SDS