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| カタログ番号 | HY448137 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | SAA0847 |
| 抱合 | APC |
| ターゲット | Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC |
| アクセッション番号 | P04839 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | NADPH oxidase 2 (CYBB/NOX2) is a ~65 kDa protein. Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS. 1. Bionda, C. et al. (2004) Human genetics 115, 418-27. PMID: 15338276 2. Noreng, S. et al. (2022) Nature communications 13, 6079. PMID: 36241643 3. Liu, R. et al. (2022) eLife 11. PMID: 36413210 4. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 5. Raad, H. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1011-22. PMID: 19028840 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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