Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), PE (HY448127)

Name: Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), PE
Brand: abinScience
SKU: HY448127
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HY448127
Reactivité des espèces	Human
Applications	FCM, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA0847
Conjugaison	PE
Cible	Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Numéro d'accès	P04839
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	NADPH oxidase 2 (CYBB/NOX2) is a ~65 kDa protein. Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS. 1. Bionda, C. et al. (2004) Human genetics 115, 418-27. PMID: 15338276 2. Noreng, S. et al. (2022) Nature communications 13, 6079. PMID: 36241643 3. Liu, R. et al. (2022) eLife 11. PMID: 36413210 4. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 5. Raad, H. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1011-22. PMID: 19028840
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CYBB/NOX2 Recombinant Antibody (SAA0847), PE.pdf

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