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Anti-Human CYLD Polyclonal Antibody (HV742014)

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Vista general
Número de catálogoHV742014
Descripción
Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CYLD (Asn553-Lys956).
Objetivo CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q9NQC7
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383
2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086
3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046
4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266
5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237
6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049
7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020
8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351
9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393
10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human CYLD Polyclonal Antibody

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