Anti-Human CYLD Polyclonal Antibody (HV742014)

Name: Anti-Human CYLD Polyclonal Antibody
Brand: abinScience
SKU: HV742014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HV742014

Description

Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CYLD (Asn553-Lys956).

Cible

CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9NQC7

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383

2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086

3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046

4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266

5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237

6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049

7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020

8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351

9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393

10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human CYLD Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human CYLD Polyclonal Antibody (HV742014)

Aperçu

Images

Reférences

Fiche technique

SDS