Anti-Human CYLD Polyclonal Antibody (HV742014)

Name: Anti-Human CYLD Polyclonal Antibody
Brand: abinScience
SKU: HV742014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HV742014

説明

Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human CYLD (Asn553-Lys956).

ターゲット

CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

エンドトキシンレベル

Please contact with the lab for this information.

精製

Purified by antigen affinity column.

アクセッション番号

Q9NQC7

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383

2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086

3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046

4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266

5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237

6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049

7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020

8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351

9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393

10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689

注意事項

For research use only

イメージ

参考文献

データシート

Anti-Human CYLD Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human CYLD Polyclonal Antibody (HV742014)

概要

イメージ

参考文献

データシート

SDS