中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY091014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP2D6 (Leu236-Gln472). | ||||||||
| ターゲット | Debrisoquine 4-hydroxylase, CYP2DL1, Cytochrome P450 2D6, Cytochrome P450-DB1, CYPIID6, Cholesterol 25-hydroxylase, CYP2D6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10635 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytochrome P450 2D6 (CYP2D6) is a ~55 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. 1. Snider, NT. et al. (2008) The Journal of pharmacology and experimental therapeutics 327, 538-45. PMID: 18698000 2. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576 3. Mesaros, C. et al. (2010) Rapid communications in mass spectrometry : RCM 24, 3237-47. PMID: 20972997 4. Sridar, C. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 782-8. PMID: 21289075 5. Honda, A. et al. (2011) Journal of lipid research 52, 1509-16. PMID: 21576599 6. Chen, H. et al. (2000) Drug metabolism and disposition: the biological fate of chemicals 28, 315-22. PMID: 10681376 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
