

| Каталожный номер | HC553014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human DDX39B/BAT1/UAP56 Polyclonal Antibody (HC553014) is a rabbit polyclonal antibody detecting DDX39B in ELISA, IHC, WB. Suitable for Bovine, Dog, Chicken, Human, and Macaca mulatta.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human DDX39B/BAT1/UAP56 (Leu259-Arg428). | ||||||||
| Цель | BAT1, Spliceosome RNA helicase DDX39B, ATP-dependent RNA helicase p47, DEAD box protein UAP56, DDX39B, UAP56, HLA-B-associated transcript 1 protein, 56 kDa U2AF65-associated protein | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q13838 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Spliceosome RNA helicase DDX39B (BAT1/UAP56) is a ~48 kDa protein. Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. 1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825 2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806 3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602 4. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911 | ||||||||
| Примечание | For research use only. |
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