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| カタログ番号 | HT313014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DDX3X (Glu161-Ser410). | ||||||||
| ターゲット | DEAD box, X isoform, CAP-Rf, DDX3, HLP2, DEAD box protein 3, X-chromosomal, DDX3X, ATP-dependent RNA helicase DDX3X, Helicase-like protein 2, DBX | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00571 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-dependent RNA helicase DDX3X is a ~73 kDa protein. Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). 1. Franca, R. et al. (2007) Proteins 67, 1128-37. PMID: 17357160 2. Garbelli, A. et al. (2011) PloS one 6, e19810. PMID: 21589879 3. Heaton, SM. et al. (2019) Cells 8. PMID: 31575075 4. Dolde, C. et al. (2018) Journal of cell science 131. PMID: 29222110 5. Herdy, B. et al. (2018) Nucleic acids research 46, 11592-11604. PMID: 30256975 6. Chao, CH. et al. (2006) Cancer research 66, 6579-88. PMID: 16818630 7. Botlagunta, M. et al. (2008) Oncogene 27, 3912-22. PMID: 18264132 | ||||||||
| 注意事項 | For research use only. |
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